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06137 a2200205 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20200330125345.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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200330b ||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780128028513 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
WM220 |
| Item number |
LAZ |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Lazarov, Orly |
| 9 (RLIN) |
1523 |
| 245 ## - TITLE STATEMENT |
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| Title |
Genes, environment and Alzheimer's disease |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Amsterdam : |
| Name of publisher, distributor, etc. |
Elsevier/Academic Press, |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xxii, 425 p. : illustrations (chiefly color) ; |
| Dimensions |
24 cm. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Machine generated contents note: 1.Molecular Mechanisms of Learning and Memory / Russell Nicholls<br/>From Plato's Wax Tablet to Genes<br/>Memory Processes<br/>Brain Structures Underlying Memory Processes<br/>Cellular Basis of Memory<br/>The Role of CREB in Memory<br/>Pathways Activating CREB<br/>HDACs/HATs Role in Gene Transcription<br/>References<br/>2.When Cognitive Decline Becomes Pathology: From Normal Aging to Alzheimer's Disease / David P. Salmon<br/>Models of Cognitive Decline in Healthy Aging<br/>Distinguishing AD-Associated Cognitive Decline from Normal Aging<br/>Distinguishing Preclinical AD from Normal Aging with Event-Related Potentials (ERPs)<br/>Memory Deficits in Preclinical AD<br/>Asymmetric Cognitive Decline in Preclinical AD<br/>Summary and Conclusions<br/>3.Adult Neurogenesis and Cognitive Function: Relevance for Disorders Associated with Human Aging / Robert J. Schloesser<br/>Introduction<br/>Identification and Characterization of Adult Neurogenesis<br/>Contents note continued: Development and Maturation of Adult-Born Neurons<br/>Adult Mammalian Hippocampal Circuitry<br/>Factors Affecting Adult Neurogenesis<br/>Proposed Functions of Adult Neurogenesis<br/>Neurogenesis, Hippocampal Dysfunction, and Alzheimer's Disease<br/>Methodologies for Studying Adult Neurogenesis<br/>Conclusion<br/>I.HALLMARKS AND GENETIC FORMS OF AD<br/>4.The Amyloid β Precursor Protein and Cognitive Function in Alzheimer's Disease / Robert A. Marr<br/>The APP Gene and Its Homologs<br/>The APP Protein, Its Domains, and Its Proteolytic Fragments<br/>Intracellular Trafficking and Processing of APP<br/>Cholesterol and APP Processing<br/>APP-Interacting Proteins: Signal Transduction and Processing<br/>Functions of APP<br/>Does Aβ Have a Function?<br/>APP Knockout Mice<br/>APP and AD<br/>5.Molecular Pathways in Alzheimer's Disease and Cognitive Function: New Insights into Pathobiology of Tau / Li Gan<br/>Contents note continued: Normal Production and Function of Tau<br/>Pathogenic Tau<br/>Tau-Mediated Neuronal Deficits<br/>Targeting Tau in AD: Therapeutic Implications<br/>II.GENETIC AND ENVIRONMENTAL RISK FACTORS<br/>6.Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease / Guojun Bu<br/>APOE Genotypes and Cognitive Functions in Nondemented Individuals<br/>APOE and Cholesterol Metabolism in Synaptic Functions<br/>APOE, Brain Glucose Metabolism, and Insulin Signaling<br/>APOE, Mitochondria Dysfunction, and Tau Phosphorylation<br/>APOE, ApoE Receptors, and Synaptic Functions<br/>APOE and Cerebrovascular Functions<br/>APOE and Inflammatory Response<br/>Summary and Perspectives<br/>Acknowledgments<br/>7.Lifestyle and Alzheimer's Disease: The Role of Environmental Factors in Disease Development / Orly Lazarov<br/>Epidemiological Studies<br/>The Benefits of Cognitive Complexity Following the Onset of Dementia<br/>Contents note continued: Physical Activity and Exercise<br/>Chemical Exposure and AD Risk<br/>Metals<br/>Air Pollution and Tobacco Smoke<br/>Nutrition and the Microbiome<br/>Sleep and Circadian Rhythm<br/>Socialization<br/>8.Role of BACE1 in Cognitive Function, from Alzheimer's Disease to Traumatic Brain Injury / Giuseppina Tesco<br/>BACE1<br/>9.Traumatic Brain Injury and Rationale for a Neuropsychological Diagnosis of Diffuse Axonal Injury / Douglas H. Smith<br/>Common TBI-Related Cognitive Deficits<br/>Mechanisms of Cognitive Disturbance Following TBI<br/>Diffuse Axonal Injury<br/>DAI as a Mechanism of Cognitive Dysfunction Following TBI<br/>Neurochemical and Neurometabolic Changes<br/>Neurometabolic Changes as a Mechanism of Cognitive Dysfunction Following TBI<br/>Focal Injuries<br/>Focal Brain Injury as a Mechanism of Cognitive Dysfunction Following TBI<br/>Neurodegenerative Processes<br/>Contents note continued: Neurodegenerative Processes as a Mechanism of Cognitive Dysfunction Following TBI<br/>Conclusions<br/>10.Alzheimer's Disease and the Sleep<br/>Wake Cycle / Li-Huei Tsai<br/>To Sleep, Perchance to Learn<br/>Sleep Disturbances and Cognitive Decline<br/>Sleep and Aβ Pathology: A Pathogenic Loop<br/>Summary and Closing Remarks<br/>11.Stroke, Cognitive Function, and Alzheimer's Disease / Alyson A. Miller<br/>Stroke: An Overview<br/>Cognitive Impairment and Dementia: AD, VaD, and VCI<br/>The Role of the NVU in AD and VCI<br/>VCI After Stroke<br/>AD and Stroke<br/>Prospects for Treatment and Prevention<br/>12.Cerebral Innate Immunity: A New Conceptual Framework for Alzheimer's Disease / Terrence Town<br/>Cerebral Innate Immunity in Alzheimer Pathoetiology<br/>An Historical Perspective: Innate Immunity in AD<br/>Contents note continued: Aβ Immunotherapy and the Role of Mononuclear Phagocytes in Amyloid Plaque Clearance<br/>Novel Strategies for Targeting Peripheral Macrophages Versus Brain-Resident Microglia<br/>Targeting Cardinal Anti-inflammatory Cytokines to Restrict Cerebral Amyloidosis<br/>Chemokines Recruit Monocytes to Aβ Plaques and Dying Neurons<br/>Blocking Inflammatory ILs 12 and 23 Prevents Plaque Buildup in Transgenic Mice<br/>PPARγ Agonists Reduce Inflammation While Boosting Microglial Aβ Uptake<br/>Inflammasome Activation in AD<br/>Beclin 1 Regulates Microglial Phagocytosis and May Be Impaired in AD<br/>A New Generation of AD Pharmacotherapeutics Targeting Innate Immunity<br/>Concluding Remarks<br/>Acknowledgements<br/>13.Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease / Marcelo G. Bonini<br/>Epidemiology<br/>T2DM: Clinical Description<br/>Mouse Models of Type 2 Diabetes<br/>Mechanism and Pathways<br/>Contents note continued: Cerebrovascular Complications in T2DM: Implications for AD Development<br/>Alzheimer's Disease: When Inflammation and Vascular Dysfunction Get to the Brain<br/>References |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Alzheimer's disease |
| 9 (RLIN) |
1524 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Alzheimer's disease - Genetic aspects |
| 9 (RLIN) |
1525 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Alzheimer's disease - Molecular aspects |
| 9 (RLIN) |
1526 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tesco, Giuseppina |
| 9 (RLIN) |
1527 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Books |
