Contents:

SECTION I Basic science
1.Genetics of Huntington disease /​ M.A. Nance
2.Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies /​ R.L. Margolis
SECTION II Clinical aspects
3.Epidemiology of Huntington disease /​ B.R. Leavitt
4.Statistical modeling of Huntington disease onset /​ Y. Wang
5.The diagnosis and natural history of Huntington disease /​ M. Altshuler
6.Cognitive and behavioral changes in Huntington disease before diagnosis /​ E. Shaw
7.Preclinical motor manifestations of Huntington disease /​ K.M. Biglan
8.The highly anxious individual presenting for Huntington disease-predictive genetic testing: the psychiatrist's role in assessment and counseling /​ M. Groves
9.Preimplantation genetics and other reproductive options in Huntington disease /​ P.C. Sacks
10.Genetic testing for Huntington disease /​ K.A. Quaid
SECTION III Treatment of Huntington disease
Contents note continued: 11.Medical treatment of behavioral manifestations of Huntington disease /​ E. van Duijn
12.Medical management of motor manifestations of Huntington disease /​ C. T. Loy
13.The role of rehabilitation therapy in Huntington disease /​ M. Busse
14.Contemporary health care for Huntington disease /​ L. Goodman
15.The impact of Huntington disease on young people /​ M. Ellison
16.Making a measurable difference in advanced Huntington disease care /​ A.K. Rao
SECTION IV Experimental therapeutics
17.New symptomatic therapies for Huntington disease /​ C.M. Testa
18.Motor outcome measures in Huntington disease clinical trials /​ R. Schubert
19.Cognitive assessment in Huntington disease clinical drug trials /​ Y. Glikmann-Johnston
SECTION V Biomarkers
20.Structural imaging in premanifest and manifest Huntington disease /​ E.H. Aylward
21.Functional imaging in Huntington disease /​ D. Eidelberg.