Sample size tables for clinical, laboratory and epidemiology studies
Publication details: Hoboken, New Jersey : Wiley, 2018Edition: 4th edDescription: viii, 390 p. : 24 cmISBN: 9781118874943Subject(s): Clinical trials | Research design | Sample size | Statistical methodsDDC classification: W20.55.C5 Summary: Summary: This book provides statisticians and researchers with the statistical tools - equations, formulae and numerical tables - to design and plan clinical studies and carry out accurate, reliable and reproducible analysis of the data so obtained. There is no way around this as incorrect procedure in clinical studies means that the researcher's paper will not be accepted by a peer-reviewed journal. Planning and analysing clinical studies is a very complicated business and this book provides indispensible factual information.![](/opac-tmpl/bootstrap/itemtypeimg/bridge/book.png)
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576.5 LAI The fundamentals of modern statistical genetics | QV771.4 FRI Fundamentals of clinical trials | QZ52 PAK Statistics in human genetics | W20.55.C5 MAC Sample size tables for clinical, laboratory and epidemiology studies | WA105 GOR Gordis Epidemiology | WA105 ROT South Asian edition of modern Epidemiology |
Content:
1 Basic Design Considerations 1
2 Further Design Considerations 29
3 Binary Outcomes 41
4 Ordered Categorical Outcomes 55
5 Continuous Outcomes 67
6 Rate Outcomes 81
7 Survival Time Outcomes 97
8 Paired Binary, Ordered Categorical and Continuous Outcomes 115
9 Confidence Intervals 135
10 Repeated Outcome Measures 155
11 Non?]Inferiority and Equivalence 167
12 Cluster Designs 193
13 Stepped Wedge Designs 211
14 More than Two Groups Designs 225
15 Genomic Targets and Dose?]Finding 235
16 Feasibility and Pilot Studies 247
17 Therapeutic Exploratory Trials: Single Arm with Binary Outcomes 265
18 Therapeutic Exploratory Trials: Survival, Dual Endpoints, Randomised and Genomic Targets 281
19 The Correlation Coefficient 303
20 Observer Agreement Studies 315
21 Reference Intervals and Receiver Operating Curves 337
22 Sample Size Software 359
Cumulative References 361
Index
Summary:
This book provides statisticians and researchers with the statistical tools - equations, formulae and numerical tables - to design and plan clinical studies and carry out accurate, reliable and reproducible analysis of the data so obtained. There is no way around this as incorrect procedure in clinical studies means that the researcher's paper will not be accepted by a peer-reviewed journal. Planning and analysing clinical studies is a very complicated business and this book provides indispensible factual information.
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